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Eurofins DiscoverX MAPKAP Kinase 3 Protein, Unactive
Description
MAPKAP Kinase 3 is a stress-activated serine/threonine-protein kinase which involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.
GenBank NM_004635
Specifications
Specifications
| Formulation | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Molecular Weight (g/mol) | 69.8 kDa |
| Quantity | 250 μg |
| Species | Human |
| Recombinant | Recombinant |
| Protein Tag | N-terminal GST |
| Expression System | Recombinant enzyme expressed in E. coli cells |
| Protein Form | Truncated |
| Purity or Quality Grade | ≥68% |
| Protein | MAPKAP Kinase 3, unactive |
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