Invitrogen™ MAP4K2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA552422

Product Code. 15770371

Description

Immunogen sequence: ETDPLNEPWE EEWTLLGKEE LSGSLLQSVQ EALEERSLTI RSASEFQELD SPDDTMGTIK RAPFLGPLPT DPPAEEPLSS PPGTLPPPPS GPNSSPLLPT AWATMKQRE Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 74%.

MAP4K2 (GCK) is a serine/ threonine protein kinase that activates the JNK pathway. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of the germinal center, where it may participate in B-cell differentiation. The kinase may also play a role in the regulation of vesicle targeting or fusion. The protein encoded by MAP4K2 is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.

Specifications

• Antigen: MAP4K2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP4K2
• Gene Alias: AI385662; B lymphocyte serine/threonine protein kinase; B lymphocyte serine/threonine-protein kinase; BL44; dZ150L22.2; GC kinase; GCK; germinal center kinase; germinal centre kinase (GC kinase); LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 2; MAP4K2; map4k2l; map4k2l-2; map4k3l; MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; mitogen activated protein kinase kinase kinase kinase 2; mitogen-activated protein kinase kinase kinase kinase 2; mitogen-activated protein kinase kinase kinase kinase 2-like; mitogen-activated protein kinase kinase kinase kinase 3-like; Rab8 interacting protein; rab8-interacting protein; Rab8ip; si:dz150l22.2; si:dz263j20.1; Unknown (protein for MGC:136670); zgc:136670
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5871
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q12851
• Gene Symbols: MAP4K2
• Immunogen: Recombinant protein corresponding to Human MAP4K2. Recombinant protein control fragment (Product #RP-89768).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG