Invitrogen™ Human MAP4K2 (GCK), His Tag Recombinant Protein

Product Code. 10322303

Brand: Invitrogen™ PV4281

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length

MAP4K2 (GCK) is a serine/ threonine protein kinase that activates the JNK pathway. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of the germinal center, where it may participate in B-cell differentiation. The kinase may also play a role in the regulation of vesicle targeting or fusion. The protein encoded by MAP4K2 is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.

Specifications

• Accession Number: Q12851
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50 mM tris with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5
• Gene ID (Entrez): 5871
• Molecular Weight (g/mol): 95.6 kDa
• Name: Human MAP4K2 (GCK), His Tag
• Quantity: 1 mg
• Regulatory Status: RUO - research use only
• Gene Alias: AI385662; B lymphocyte serine/threonine protein kinase; B lymphocyte serine/threonine-protein kinase; BL44; dZ150L22.2; GC kinase; GCK; germinal center kinase; germinal centre kinase (GC kinase); LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 2; MAP4K2; map4k2l; map4k2l-2; map4k3l; MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; mitogen activated protein kinase kinase kinase kinase 2; mitogen-activated protein kinase kinase kinase kinase 2; mitogen-activated protein kinase kinase kinase kinase 2-like; mitogen-activated protein kinase kinase kinase kinase 3-like; Rab8 interacting protein; rab8-interacting protein; Rab8ip; si:dz150l22.2; si:dz263j20.1; Unknown (protein for MGC:136670); zgc:136670
• Common Name: MAP4K2
• KinaseFamily: STE20 Kinase Family
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: Full length
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Expression System: Insect cells
• Form: Liquid