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Eurofins DiscoverX MAP Kinase 1/Erk1 Protein, Unactive
Description
MAP Kinase 1 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
Gen Bank XM_055766
Specifications
Specifications
| Formulation | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 50% glycerol, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Liquid at -20°C. |
| Molecular Weight (g/mol) | 70 kDa |
| Quantity | 250 μg |
| Species | Human |
| Recombinant | Recombinant |
| Protein Tag | N-terminal GST |
| Expression System | Recombinant enzyme expressed in E. coli cells |
| Protein Form | Full-length |
| Purity or Quality Grade | ≥72% |
| Protein | MAP Kinase 1/Erk1, unactive |
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