Invitrogen™ MAGE1 Recombinant Rabbit Monoclonal Antibody (PD00-50)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA550722

Product Code. 17929332

Description

Positive control: Human malignant melanoma tissue, human testis tissue. Predicted band size: 34 kDa Subcellular Location: Cytoplasm, Nucleus.

Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanoma associated with antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various hisological tyoes (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

Specifications

• Antigen: MAGE1
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P43355
• Gene Symbols: MAGEA1
• Immunogen: Synthetic peptide aa 1-309/309.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: PD00-50
• Conjugate: Unconjugated
• Gene: MAGEA1
• Gene Alias: antigen MZ2-E; antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5; cancer/testis antigen 1.1; cancer/testis antigen family 1, member 1; CD228; CT1.1; mage 1; MAGE family member A1; MAGE1; mage-1; MAGE-1 antigen; MAGE1A; MAGEA1; Mage-a1; MAP97; melanoma antigen family A 1; melanoma antigen family A, 1; melanoma antigen family A, 1 (directs expression of antigen MZ2-E); melanoma antigen family A1; melanoma antigen MAGE-1; melanoma antigen, family A, 1; melanoma-associated antigen 1; melanoma-associated antigen MZ2-E; Melanoma-associated antigen p97; melanoma-associated antigen p97, isoform 2; melanotransferrin; MELTF; membrane-bound transferrin-like protein; Mfi2; MTf; MTF1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 4100
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid