Invitrogen™ LYPD8 Monoclonal Antibody (961703)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA561988

Product Code. 30534706

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

LYPD8 (Ly6/PLAUR domain-containing 8) is a gene that encodes a protein involved in the regulation of the intestinal immune system and maintenance of gut homeostasis. The LYPD8 protein is primarily expressed in the epithelial cells of the colon and plays a crucial role in protecting the intestinal lining from pathogenic bacteria. It achieves this by binding to flagellated bacteria, thereby preventing their motility and subsequent invasion of the gut epithelium. This action helps to maintain a balanced microbial environment and prevents inflammation that can lead to conditions such as colitis. LYPD8 is part of the broader Ly6/uPAR protein family, which is known for its involvement in immune responses and cell signaling. Alterations or deficiencies in LYPD8 expression have been linked to an increased susceptibility to inflammatory bowel diseases (IBD) and other gastrointestinal disorders. Understanding the function and regulatory mechanisms of LYPD8 is essential for developing new therapeutic strategies aimed at enhancing gut barrier function and treating inflammatory conditions of the intestine. Research into LYPD8 also provides valuable insights into host-microbe interactions and the maintenance of mucosal immunity.

Specifications

• Antigen: LYPD8
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and no preservative
• Immunogen: Human embryonic kidney cell line HEK293-derived transfected with human LYPD8, Met1-Asn215.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized

• Applications: Flow Cytometry, Immunocytochemistry
• Clone: 961703
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1