missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ LYN 1604 dihydrochloride

Tocris Bioscience™ LYN 1604 dihydrochloride
GREENER_CHOICE

Product Code. 18748106
Change view
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
18748106 50 mg 50mg
18747706 10 mg 10mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 18748106 Supplier Tocris Bioscience™ Supplier No. 6617/50

Please to purchase this item. Need a web account? Register with us today!

480.70 GBP valid until 2026-04-30
BEST PRICE on Promo! Use promo code "27934" to get your promotional price.
This item is not returnable. View return policy

Description

Potent UNC-51-like kinase 1 (ULK1) agonist

LYN 1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) agonist (EC50 = 18.94 nM). In MDA-MB-231 cells, LYN 1604 induces upregulation of Beclin-1, LC3-I and LC3-II, as well as degradation of p62. LYN 1604 induces cell death (IC50 = 1.66 μM) via the ULK complex involving both autophagy and apoptosis pathway effectors (e.g. ATF3, RAD21, and caspase-3); this effect is reversible by the autophagy inhibitor 3-methyladenine (Cat. No. 3977). LYN 1604 inhibits tumor growth in a mouse xenograft model, decreases bone loss in a mouse model of osteoporosis and reduces the formation of TRAP-positive multinucleated cells.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 2-[Bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]ethanone dihydrochloride
CAS 2310109-38-5
Quantity 50 mg
Target ULK1
Molecular Formula C33H43Cl2N3O2.2HCl
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.