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LY2811376, MedChemExpress

Product Code. 16464996
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Product Code. 16464996

Brand: Medchem Express HY10472

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Description

MedChemExpress LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.

LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.

Specifications

Chemical Name or Material LY2811376
CAS 1194044-20-6
Color Earth Yellow
Purity Grade Notes Research
Molecular Formula C15H14F2N4S
Quantity 100 mg
Solubility Information DMSO : ≥ 31 mg/mL (96.77 mM)
SMILES FC1=C(C2=CN=CN=C2)C=C([C@]3(C)CCSC(N3)=N)C(F)=C1
Molecular Weight (g/mol) 320.36
Formula Weight 320.36
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neurodegeneration
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Research purposes only

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