Invitrogen™ Ly-108 Monoclonal Antibody (eBio13G3-19D (13G3-19D)), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
15237247	Invitrogen™ 14-1508-80	25 μg
15247247	Invitrogen™ 14-1508-82	100 μg

Description

Description: The eBio13G3-19D monoclonal antibody reacts with mouse Ly108, the mouse homologue of human SLAMF6 (signaling lymphocyte activation molecule family member 6). Mouse Ly108 is also known as NTB-A (NK cell, T cell, B cell antigen), and is expressed on NK, T cells, and B cells. Engagement of the Ly108 receptor enhances NK cell activity and expression of IFN-gamma, and contributes to the inability of NK cells to kill Epstein Barr virus-infected B cells in X-linked lymphoproliferative disease. CD4+ T cells from Ly108 knock-out mice exhibit diminished ability to produce IL-4 and defective neutrophil functions. Staining has not revealed any strain differences between C57BL/6 and BALB/c mice. Other strains have not been tested. Applications Reported: This eBio13G3-19D (13G3-19D) antibody has been reported for use in flow cytometric analysis, immunoprecipitation, and immunoblotting (WB). Applications Tested: This eBio13G3-19D (13G3-19D) antibody has been tested by flow cytometric analysis of mouse splenocytes and thymocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Ly108 is the mouse homologue of human SLAMF6 (signaling lymphocyte activation molecule family member 6). Mouse Ly108 is expressed on NK, B cells, and T cells. Activation of Ly108 receptor enhances NK cell activity and IFN-gamma expression.

Specifications

• Antigen: Ly-108
• Concentration: 0.5 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.09% sodium azide; pH 8.0
• Gene Alias: Activating NK receptor; CD352; KAL1; KAL1b; KALI; KALIb; Ly108; Lymphocyte antigen 108; natural killer-, T- and B-cell antigen; NK-T-B-antigen; NTBA; NTB-A; NTBA receptor; RGD1561848; SF2000; SLAM family member 6; Slamf6; UNQ6123/PRO20080
• Gene Symbols: SLAMF6
• Primary or Secondary: Primary
• Content And Storage: 4°C
• Gene: SLAMF6

• Clone: eBio13G3-19D (13G3-19D)
• Applications: Flow Cytometry, Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Mouse
• Gene Accession No.: Q9ET39
• Gene ID (Entrez): 30925
• Isotype: IgG2a κ
• Purification Method: Affinity chromatography
• Product Type: Antibody

For Research Use Only.