Invitrogen™ LXR alpha/beta Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA1331B

Product Code. 11577102

Description

PA1-331B detects recombinant human liver X receptor (LXR). PA1-331B has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~64 kDa and ~80 kDa protein representing recombinant human LXR alpha and beta. The PA1-331B immunogen is a synthetic peptide corresponding to residues C L(432) R L Q D K K L P P L L S E(445) of human LXR alpha. This sequence also corresponds to amino acids 442-455 of the human LXR beta. PA1-331B immunizing peptide (Cat. # PEP-115) is available for use in neutralization and control experiments.

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activiation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiqutination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.

Specifications

• Antigen: LXR alpha/beta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NR1H3
• Gene Alias: AI194859; AU018371; liver X nuclear receptor alpha variant 1; liver X nuclear receptor beta; Liver X Receptor; liver X receptor alpha; Liver X receptor beta; LX receptor beta; LXR; LXR alpha; LXR beta; LXRA; LXR-a; LXRalpha; LXRB; LXR-b; LXRbeta; NER; NER1; NER-I; NR1H2; NR1H3; nuclear orphan receptor LXR-alpha; nuclear orphan receptor LXR-beta; nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 2; nuclear receptor subfamily 1, group H, member 3; OR-1; Orphan nuclear receptor OR-1; oxysterols receptor LXR-alpha; Oxysterols receptor LXR-beta; retinoid X receptor-interacting protein No.15; Rip15; RLD1; RLD-1; steroid hormone-nuclear receptor NER; ubiquitous receptor; ubiquitously-expressed nuclear receptor; ubiquitously-expressed nuclear receptor 1; ubiquitously-expressed nuclear receptor 2; Unr; Unr1; Unr2; UR
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10062, 7376
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P55055, Q13133
• Gene Symbols: NR1H2, NR1H3
• Immunogen: Synthetic peptide corresponding to residues C L(432) R L Q D K K L P P L L S E(445) of human LXR alpha.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG