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Invitrogen™ LXR alpha/beta Polyclonal Antibody
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Product Code. 11577102
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Quantity:
200 μg
Unit Size:
200µg
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11577102 200 μg 200µg
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Product Code. 11577102 Supplier Invitrogen™ Supplier No. PA1331B

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Description

Rabbit Polyclonal Antibody

PA1-331B detects recombinant human liver X receptor (LXR). PA1-331B has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~64 kDa and ~80 kDa protein representing recombinant human LXR alpha and beta. The PA1-331B immunogen is a synthetic peptide corresponding to residues C L(432) R L Q D K K L P P L L S E(445) of human LXR alpha. This sequence also corresponds to amino acids 442-455 of the human LXR beta. PA1-331B immunizing peptide (Cat. # PEP-115) is available for use in neutralization and control experiments.

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activiation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiqutination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LXR alpha/beta
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene NR1H3
Gene Accession No. P55055, Q13133
Gene Alias AI194859; AU018371; liver X nuclear receptor alpha variant 1; liver X nuclear receptor beta; Liver X Receptor; liver X receptor alpha; Liver X receptor beta; LX receptor beta; LXR; LXR alpha; LXR beta; LXRA; LXR-a; LXRalpha; LXRB; LXR-b; LXRbeta; NER; NER1; NER-I; NR1H2; NR1H3; nuclear orphan receptor LXR-alpha; nuclear orphan receptor LXR-beta; nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 2; nuclear receptor subfamily 1, group H, member 3; OR-1; Orphan nuclear receptor OR-1; oxysterols receptor LXR-alpha; Oxysterols receptor LXR-beta; retinoid X receptor-interacting protein No.15; Rip15; RLD1; RLD-1; steroid hormone-nuclear receptor NER; ubiquitous receptor; ubiquitously-expressed nuclear receptor; ubiquitously-expressed nuclear receptor 1; ubiquitously-expressed nuclear receptor 2; Unr; Unr1; Unr2; UR
Gene Symbols NR1H2, NR1H3
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues C L(432) R L Q D K K L P P L L S E(445) of human LXR alpha.
Purification Method Antigen Affinity Chromatography
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10062, 7376
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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