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Invitrogen™ LRRTM3 Polyclonal Antibody

Product Code. 12839242
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Quantity:
100 μg
Unit Size:
100µg
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12839242 100 μg 100µg
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Product Code. 12839242 Supplier Invitrogen™ Supplier No. PA521098

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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse brain tissue lysate. PA5-21098 can be used with blocking peptide PEP-1212.

The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the A-beta42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma A-beta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LRRTM3
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene LRRTM3
Gene Accession No. D3ZAL8, Q86VH5, Q8BZ81
Gene Alias 9630044H04Rik; leucine rich repeat transmembrane neuronal 3; leucine-rich repeat transmembrane neuronal protein 3; LRRTM3; UNQ803/PRO1693
Gene Symbols LRRTM3
Host Species Rabbit
Immunogen An 18 amino acid peptide near the carboxy terminus of human LRRTM3.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 216028, 294380, 347731
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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