Invitrogen™ LRRTM3 Monoclonal Antibody (568318)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA561497

Product Code. 30536094

Description

Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.

The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the A-beta42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma A-beta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.

Specifications

• Antigen: LRRTM3
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and no preservative
• Gene Accession No.: Q86VH5
• Gene Symbols: LRRTM3
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human LRRTM3, Glu31-Lys419.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (Paraffin)
• Clone: 568318
• Conjugate: Unconjugated
• Gene: LRRTM3
• Gene Alias: 9630044H04Rik; leucine rich repeat transmembrane neuronal 3; leucine-rich repeat transmembrane neuronal protein 3; LRRTM3; UNQ803/PRO1693
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 347731
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized