LRRC25 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Thermo Scientific PA556155

Product Code. 15714071

Description

Immunogen sequence: EPSCTVSSAD VDWNAEFSAT CLNFSGLSLS LPHNQSLRAS NVILLDLSGN GLRELPVTFF AHLQKLEVLN VLRNPLSRVD GALAARCDLD LQADCNCALE SWHDIRRDNC SGQKPLLCWD TTSSQHNLSA Highest antigen sequence identity to the following orthologs: Mouse - 52%, Rat - 53%.

Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164). Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. [UniProt]

Specifications

• Antigen: LRRC25
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LRRC25
• Gene Alias: leucine rich repeat containing 25; leucine-rich repeat-containing protein 25; LRRC25; MAPA; monocyte and plasmacytoid activated molecule; monocyte and plasmacytoid-activated protein; UNQ6169/PRO20174
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 126364
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: Lot-Specific
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8N386
• Gene Symbols: LRRC25
• Immunogen: Recombinant protein corresponding to Human LRRC25
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Research Use Only