Invitrogen™ LRRC15 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA557298

Product Code. 15795191

Description

Immunogen sequence: NWLLLNQPRL GTDTVPVCFS PANVRGQSLI IINVNVAVPS VHVPEVPSYP ETPWYPDTPS YPDTTSVSST TELTSPVEDY TDLTTIQVTD DRSVW Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 73%.

Leucine-rich repeats (LRRs) are 20-29 amino acid motifs that mediate protein-protein interactions. The primary function of these motifs is to provide a versatile structural framework for the formation of these protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. Several human diseases are associated with mutations in genes encoding LRR-containing proteins. The leucine-rich repeat-containing protein 15 (LRRC15, also designated LIB) is a 581 amino acid protein that contains 15 LRR repeats and is involved in cell-cell and/or -extracellular matrix interactions. LRRC15 is frequently overexpressed in multiple tumor types, most notably breast carcinoma. It is also associated with the pathogenesis of Alzheimer's disease.

Specifications

• Antigen: LRRC15
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LRRC15
• Gene Alias: 5430427N11Rik; hLib; leucine rich repeat containing 15; Leucine-rich repeat protein induced by amyloid-beta; leucine-rich repeat protein induced by beta amyloid; leucine-rich repeat protein induced by beta-amyloid; leucine-rich repeat protein induced by beta-amyloid homolog; Leucine-rich repeat-containing protein 15; LIB; Lrrc15; rLib
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 131578
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.20 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8TF66
• Gene Symbols: LRRC15
• Immunogen: Recombinant protein corresponding to Human LRRC15. Recombinant protein control fragment (Product #RP-95705).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG