Invitrogen™ LRP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA564182

Product Code. 15721952

Description

Immunogen sequence: NNDRIYWSDF KEDVIETIKY DGTDRRVIAK EAMNPYSLDI FEDQLYWISK EKGEVWKQNK FGQGKKEKTL VVNPWLTQVR IFHQLRYNKS VP Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 79%.

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

Specifications

• Antigen: LRP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Lrp2
• Gene Alias: AI315343; AW536255; b2b1625.2Clo; calcium sensor protein; D230004K18Rik; DBS; Glycoprotein 330; Gp330; Heymann nephritis antigen homolog; LDL receptor related protein 2; low density lipoprotein receptor-related protein 2; low density lipoprotein-related protein 2; low-density lipoprotein receptor-related protein 2; Lrp2; LRP-2; Megalin
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4036
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P98164
• Gene Symbols: Lrp2
• Immunogen: Recombinant protein corresponding to Human LRP2. Recombinant protein control fragment (Product #RP-103570).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG