LRAT Polyclonal Antibody, Invitrogen™

Product Code.	Quantity	unitSize
15505481	100 μg	100µg

Product Code. 15505481 Supplier Invitrogen Supplier No. PA538556

Description

Rabbit Polyclonal Antibody

Lecithin retinol acyltransferase (LRAT) is a membrane bound enzyme that catalyzes the transfer of an acyl group from the sn-1 position of lecithin to vitamin A which generates all-trans-retinyl esters (tREs) in the liver, some extrahepatic tissues, such as the lung, and retinal pigmented epithelium. LRAT can also exchange palmitoyl groups between RPE65, a tRE binding protein essential for vision, and tREs, which is important for the operation of the visual pathway. LRAT is essential for the dietary mobilization, transport, and storage of vitamin A as well as the synthesis of the visual pigment chromophore. LRAT monomers interact in membranes to form homodimers through disulfide bond formation. A loss of LRAT correlates with an early onset severe retinal dystrophy and severe retinyl ester deprivation, while a reduction in LRAT expression may be associated with invasive bladder cancer.

Specifications

• Antigen: LRAT
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: LRAT
• Gene Accession No.: O95237, Q9JI60, Q9JI61
• Gene Alias: Lecithin retinol acyltransferase, Phosphatidylcholine--retinol O-acyltransferase, Phosphatidylcholine-retinol O-acyltransferase
• Gene Symbols: LRAT
• Host Species: Rabbit
• Immunogen: A synthetic peptide derived from the internal region of human LRAT
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 64047, 79235, 9227
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG