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Invitrogen™ LPIN1 Monoclonal Antibody (OTI1B7)
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Product Code. 15936364
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Quantity:
100 μL
Unit Size:
100µL
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15936364 100 μL 100µL
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Product Code. 15936364 Supplier Invitrogen™ Supplier No. MA526770

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Description

Mouse Monoclonal Antibody

LPIN1 Monoclonal Antibody for Western Blot, IHC (P)

The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LPIN1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1B7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene LPIN1
Gene Accession No. Q14693
Gene Alias 4631420P06; DKFZp781P1796; Fatty liver dystrophy protein; Fld; KIAA0188; lipin 1; Lipin1; lipin-1; LPIN1; mKIAA0188; PAP1; Phosphatidate phosphatase LPIN1
Gene Symbols LPIN1
Host Species Mouse
Immunogen Full length human recombinant protein of LPIN1 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23175
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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