Invitrogen™ LPIN1 Monoclonal Antibody (3D9)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA521419

Product Code. 15558992

Description

Peptide Sequence: EPFYAAFGNR PADVYSYKQV GVSLNRIFTV NPKGELVQEH AKTNISSYVR LCEVVDHVFP LLKRSHSSDF PCSDTFSNFT FWREPLPPFE NQDIHSASA.

The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.

Specifications

• Antigen: LPIN1
• Classification: Monoclonal
• Concentration: 0.2-1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q14693
• Gene Symbols: LPIN1
• Immunogen: LPIN1 (NP_663731.1, 792 a.a. ~ 890 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Western Blot
• Clone: 3D9
• Conjugate: Unconjugated
• Gene: LPIN1
• Gene Alias: 4631420P06; DKFZp781P1796; Fatty liver dystrophy protein; Fld; KIAA0188; lipin 1; Lipin1; lipin-1; LPIN1; mKIAA0188; PAP1; Phosphatidate phosphatase LPIN1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23175
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid