Invitrogen™ LOXL1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA587701

Product Code. 16546131

Description

Immunogen sequence: RQAPSLPLPG RVGSDTVRGQ ARHPFGFGQV PDNWREVAVG DSTGMARART SVSQQRHGGS ASSVSASAFA STYRQQPSYP QQFPYPQAPF VSQYENYDPA SRTYDQGFVY YRPAGGGVGA GAAAVASAGV IYPYQPRARY EEYGGGEELP EYPPQGFYPA PERPYVPPPP PPPDGLDRRY SHSLYSEGTP GFEQAYPDPG PEAAQAHGGD PRLGWYPPYA NPPPEAYGPP RALEPPYLPV RSSDTPPPGG ERNGAQQGRL SVGSVYRPNQ NGRGLP; Positive Samples: HeLa, A375, A-549, BT-474, HT-1080, Mouse lung, Mouse heart, Rat heart; Cellular Location: extracellular space.

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Specifications

• Antigen: LOXL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Loxl1
• Gene Alias: cross-linking enzyme; LOL; Lox2; LOXL; LOXL1; Lysyl oxidase 2; lysyl oxidase homolog 1; lysyl oxidase like 1; lysyl oxidase-like 1; lysyl oxidase-like protein 1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16949
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.05 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P97873
• Gene Symbols: Loxl1
• Immunogen: Recombinant protein (or fragment).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG