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Loperamide hydrochloride, Tocris Bioscience™

Product Code. 30001135
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1 g
Unit Size:
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Product Code. 30001135 Supplier Tocris Bioscience Supplier No. 0840/1G

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Description

Peripherally acting μ agonist; Ca2+ channel blocker

High affinity μ-opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for μ-, δ- and κ-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca2+ channels and at higher concentrations it reduces Ca2+ flux through NMDA receptor operated channels.
TRUSTED_SUSTAINABILITY

Specifications

CAS 34552-83-5
Molecular Formula C29H34Cl2N2O2
Quantity 1 g
Synonym loperamide hydrochloride, loperamide hcl, imodium, suprasec, dissenten, fortasec, lopemid, lopemin, loperyl, imosec
InChI Key PGYPOBZJRVSMDS-UHFFFAOYSA-N
SMILES CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl
IUPAC Name 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide;hydrochloride
Molecular Weight (g/mol) 513.503
PubChem CID 71420
ChEBI CHEBI:6533
Formula Weight 513.51
Percent Purity >99%
Chemical Name or Material Loperamide hydrochloride
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