LMNB2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 10895-1-AP-20UL

Product Code. 16867583

Description

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i. e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i. e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i. e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but domit genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.

Specifications

• Antigen: LMNB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LMNB2
• Gene Alias: LAMB2, lamin B2, LMN2, LMNB2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16907, 299625, 84823
• Content And Storage: -20°C
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunofluorescence, Immunocytochemistry
• Concentration: 0.13 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: P21619, Q03252
• Gene Symbols: LMNB2
• Immunogen: LMNB2 Fusion Protein Ag1335
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Rat, Mouse, Human
• Product Type: Antibody
• Isotype: IgG