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Tocris Bioscience™ LL 37
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Product Code. 18718048
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1mg
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18718048 1mg
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Product Code. 18718048

Brand: Tocris Bioscience™ 5213/1

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279.60 GBP valid until 2026-03-31
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Description

Antimicrobial peptide derivative of human cathelicidin

LL 37 is an antimicrobial peptide derivative of human cathelicidin. Induces FPRL1-mediated chemotaxis of human neutrophils, monocytes and T cells in vitro. Promotes wound healing following skin-targeted electroporation of a plasmid encoding hCAP-18/LL-37 in mice. LL 37 reduces SARS-CoV-2 infection by blocking the receptor binding domain of the S1 spike protein (Kd = 11.2 nM) and by binding to ACE2 (Kd = 25.5.nM). LL 37 inhibits SARS-CoV-2 pseudovirion infection (IC50 = 4.74 μg/mL) in vitro and in vivo. Also triggers apoptosis in colon cancer cells. Cell permeable.
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Specifications

Molecular Weight (g/mol) 4493.32
Product Type LL 37
Quantity 1 mg

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