Livin Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA519990

Product Code. 12828202

Description

In Western blot applications, this antibody detects a band at ∽33kDa. A suggested positive control is Raji cell lysate. PA5-19990 can be used with blocking peptide PEP-0114.

The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. Recently, it has been identified that a novel human inhibitor of apoptosis protein (IAP) family member termed Livin or ML-IAP, which contains a single baculoviral IAP repeat (BIR) domain and a COOH-terminal RING finger domain. Livin gene has two splicing variants that contain open reading frames of 298 and 280 amino acids and both contained a single copy of baculovirus IAP repeat (BIR) and RING domain. Both of the isoforms inhibit TNFa induced apoptosis in Jurkat cells. Livin expression is low in adult tissues. It is relatively expressed at a higher level in developmental tissues and in many cancer cells.

Specifications

• Antigen: Livin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BIRC7
• Gene Alias: baculoviral IAP repeat containing 7; baculoviral IAP repeat-containing 7; baculoviral IAP repeat-containing 7 (livin); baculoviral IAP repeat-containing protein 7; Baculoviral IAP repeat-containing protein 7 30 kDa subunit; Baculoviral IAP repeat-containing protein 7 30kDa subunit; Birc7; E130019N06; KIAP; Kidney inhibitor of apoptosis protein; LIVIN; livin inhibitor of apoptosis; melanoma inhibitor of apoptosis protein; MLIAP; ML-IAP; RGD1562883; RING finger protein 50; RING-type E3 ubiquitin transferase BIRC7; RNF50; RP11-261N11.7; Truncated livin; UNQ5800/PRO19607/PRO21344
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79444
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q96CA5
• Gene Symbols: BIRC7
• Immunogen: A synthetic peptide corresponding to amino acids 264 to 280 of the short form and 281 to 298 of the long form of human Livin
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG