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  5. Tocris Bioscience™ Linifanib

Tocris Bioscience™ Linifanib
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Product Code. 18799036
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18799036 50 mg 50mg
18758316 10 mg 10mg
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Product Code. 18799036 Supplier Tocris Bioscience™ Supplier No. 7743/50

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Description

Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R

Linifanib is a potent receptor tyrosine kinase (RTK) inhibitor. It inhibits PDGFRβ, KDR, FLT3, CSF-1R (IC50 values are 2, 4, 4 and 7 nM, respectively). Linifanib inhibits angiogenesis in vascularized micro-organs and potently inhibits VEGF-stimulated endothelial cell proliferation (IC50 = 0.2 nM). Linifanib also promotes the generation and reprogramming of iPSCs from somatic cells.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-[4-(3-Amino-1 H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
CAS 796967-16-3
Quantity 50 mg
Target PDGF R beta
Molecular Formula C21H18FN5O
Purity 0.98
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