Invitrogen™ LINGO2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA567714

Product Code. 15882824

Description

Predicted to react with Mouse samples.

Leucine-rich repeat and immunoglobulin-like domain-containing protein 2 (LINGO2) is a gene located on chromosome 9q34.3, encoding a transmembrane protein predominantly expressed in the central nervous system. Structurally, LINGO2 features leucine-rich repeat (LRR) domains and immunoglobulin-like domains, which are crucial for molecular interactions and signaling. Functionally, LINGO2 is involved in regulating neural growth and development, influencing processes such as axon guidance and synaptic plasticity. It modulates neurotransmitter receptor activity and intracellular signaling pathways essential for neural transmission, with implications for both normal cognitive function and neurological disorders. Altered expression of LINGO2 has been associated with movement disorders, as well as neurodegenerative conditions, suggesting its role in neural circuit integrity. Current research on LINGO2 is exploring its potential as a therapeutic target for enhancing neural repair mechanisms and addressing synaptic dysfunction, providing insights into interventions for neurological diseases.

Specifications

• Antigen: LINGO2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LINGO2
• Gene Alias: B230217C06Rik; LERN3; LERN3FLJ31810; leucine rich repeat and Ig domain containing 2; leucine rich repeat neuronal 6C; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2; Leucine-rich repeat neuronal protein 3; leucine-rich repeat neuronal protein 6C; Lingo2; LRRN6C; RGD1310773; UNQ9234/PRO31993
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 158038, 242384
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 30% glycerol, 0.87% NaCl and 0.01% sodium azide; pH 7.3
• Gene Accession No.: Q3URE9, Q7L985
• Gene Symbols: LINGO2
• Immunogen: Synthesized peptide derived from human LINGO2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG