Invitrogen™ LIN7B Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA531018

Product Code. 13455527

Description

Recommended positive controls: 293T, A431. Predicted reactivity: Mouse (97%), Rat (97%), Zebrafish (92%), Pig (99%), Chicken (86%), Rhesus Monkey (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.

Specifications

• Antigen: LIN7B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LIN7B
• Gene Alias: hLin7B; hVeli2; lin 7 homolog b; lin-7 homolog B; lin-7 homolog B (C. elegans); lin-7 homolog B, crumbs cell polarity complex component; lin-7-A; LIN7B; lin-7B; MALS2; MALS-2; Mammalian lin-seven protein 2; protein lin-7 homolog B; UNQ3116/PRO10200; Veli1a; Veli2; Veli-2; veli-2 protein; vertebrate homolog of C. elegans Lin-7 type 2; vertebrate lin-7 homolog 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64130
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.69 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9HAP6
• Gene Symbols: LIN7B
• Immunogen: Recombinant protein encompassing a sequence within the center region of human LIN7B. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG