Invitrogen™ LIN28A Monoclonal Antibody (GT717)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA531461

Product Code. 16324904

Description

Keep as concentrated solution. Predicted reactivity: Mouse (98%), Rat (98%), Cat (96%), Pig (96%), Chicken (82%), Sheep (97%), Bovine (96%). Positive Control: NT2D1, human ESC, LIN28 transfected HeLa lysates, mouse placenta. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

Specifications

• Antigen: LIN28A
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q8K3Y3, Q9H9Z2
• Gene Symbols: LIN28A
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Lin28A. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: GT717
• Conjugate: Unconjugated
• Gene: LIN28A
• Gene Alias: AL024421; CSDD1; ENSMUSG00000070700; FLJ12457; Gm10299; Lin28; LIN-28; lin-28 homolog A; lin-28 homolog A (C. elegans); Lin28a; lin-28A; Protein lin-28 homolog A; RGD1566408; RNA-binding protein LIN-28; sb:cb650; si:ch211-232d9.4; similar to RNA-binding protein LIN-28; testis expressed gene 17; testis-expressed protein 17; Tex17; ZCCHC1; zgc:55584; Zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 79727, 83557
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid