LIN28A Monoclonal Antibody (14E6-4E6), HRP, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA1016HRP

Product Code. 15362867

Description

MA1-016-HRP has been successfully used in Western blot applications on human and mouse samples.

LIN28A/B are expressed in various cancers and ES cells. LIN28 is a cytoplasmic protein, that acts as a ′translational enhancer′, driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. LIN28 is a negative regulator of microRNA (miRNA) biogenesis by specifically binding the precursor of let-7 (pre-let-7). Let-7 miRNAs have been implicated in repression of oncogenes such as ras and myc. LIN28 expression decreases during differentiation of ES cells or upon induction of neuronal differentiation by retinoic acid.

Specifications

• Antigen: LIN28A
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Gene: LIN28A
• Gene Alias: Lin-28 homolog A (C. elegans), RNA-binding protein LIN-28, LIN28A, CSDD1, Zinc finger CCHC domain-containing protein 1, ZCCHC1
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 79727, 83557
• Content And Storage: 4° C, do not freeze
• Form: Liquid

• Applications: Western Blot
• Clone: 14E6-4E6
• Conjugate: HRP
• Gene Accession No.: Q9H9Z2, Q8K3Y3
• Gene Symbols: LIN28A
• Immunogen: Full-length human recombit protein expressed in bacteria
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2a