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Invitrogen™ LIMP2 Polyclonal Antibody

Product Code. 12838722
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12838722 100 μg 100µg
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Product Code. 12838722 Supplier Invitrogen™ Supplier No. PA520544

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Description

Rabbit Polyclonal Antibody

Despite its predicted molecular weight, LIMP2 often migrates at 80-85kDa in SDS-PAGE. A suggested positive control is human skeletal muscle tissue lysate. PA5-20544 can be used with blocking peptide PEP-0664.

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LIMP2
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SCARB2
Gene Accession No. O35114, Q14108
Gene Alias 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; 9330185J12Rik; AMRF; CD 36; CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 antigen-like 2; CD36 molecule; Cd36l2; EPM4; HLGP85; I79_021583; LGP85; LIMP II; LIMP2; LIMP-2; LIMPII; Lysosome membrane protein 2; lysosome membrane protein II; MLGP85; Scarb2; Scavenger receptor class B member 2; scavenger receptor class B, member 2; sCD 36; sCD36; soluble CD 36; soluble CD36; SR-B2; SR-BII
Gene Symbols SCARB2
Host Species Rabbit
Immunogen An 18 amino acid peptide from near the carboxy terminus of human LIMP2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12492, 950
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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