LGR5 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA585604

Product Code. 16382535

Description

Keep as concentrated solution. Predicted reactivity: Mouse (84%), Rat (83%), Pig (91%), Bovine (90%). Positive Control: unboiled LGR5-transfected 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

G protein-coupled receptor GPR49 has been reported to be expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries and from human germ cell, uterus, and brain libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "e;turn-off"e; activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: LGR5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Lgr5
• Gene Alias: Fex; follicle expressed hormone; G protein-coupled receptor 49; GPR49; GPR67; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; GRP49; HG38; leucine rich repeat containing G protein coupled receptor 5; leucine rich repeat containing G protein-coupled receptor 5; leucine-rich repeat containing G protein-coupled receptor 5; leucine-rich repeat-containing G protein-coupled receptor 5; leucine-rich repeat-containing G-protein coupled receptor 5; Lgr5; orphan G protein-coupled receptor HG38; orphan G-protein coupled receptor FEX
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8549
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: O75473
• Gene Symbols: Lgr5
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human LGR5.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG