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  6. Invitrogen™ LGMN Recombinant Rabbit Monoclonal Antibody (K01_1T44)

Invitrogen™ LGMN Recombinant Rabbit Monoclonal Antibody (K01_1T44)
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Product Code. 30826180
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30828226 50 μL
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Product Code. 30826180 Supplier Invitrogen™ Supplier No. MA563404

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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: VYATTAANPR ESSYACYYDE KRSTYLGDWY SVNWMEDSDV EDLTKETLHK QYHLVKSHTN TSHVMQYGNK TISTMKVMQF QGMKRKASSP VPLPPVTHLD LTPSPDVP Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 94%, Pig - 86%, Cynomolgus monkey - 97%.

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
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Specifications

Antigen LGMN
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_1T44
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 0.05% BSA, 150mM NaCl, 40% glycerol and 0.01% sodium azide; pH 7.4
Gene LGMN
Gene Accession No. Q99538
Gene Alias AEP; AI746452; Asparaginyl endopeptidase; AU022324; cb173; cb460; cysteine protease 1; legumain; Lgmn; LGMN1; preprolegumain; protease, cysteine 1; protease, cysteine, 1; protease, cysteine, 1 (legumain); PRSC1; PRSC1EC 3.4.22.34; sb:cb173; wu:fa98g05; wu:fj92g08; zgc:76953
Gene Symbols LGMN
Host Species Rabbit
Immunogen Recombinant protein of human Legumain (aa 204-311).
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5641
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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