Invitrogen™ LGMN Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA587990

Product Code. 16536341

Description

Positive Samples: Mouse lung, Mouse liver; Cellular Location: Lysosome Immunogen sequence: GGKHWVVIVA GSNGWYNYRH QADACHAYQI IHRNGIPDEQ IVVMMYDDIA YSEDNPTPGI VINRPNGTDV YQGVPKDYTG EDVTPQNFLA VLRGDAEAVK GIGSGKVLKS GPQDHVFIYF TDHGSTGILV FPNEDLHVKD LNETIHYMYK HKMYRKMVFY IEACESGSMM NHLPDNINVY ATTAANPRES SYACYYDEKR STYLGDWYSV NWMEDSDVED LTKETLHKQY HLVKSHTNTS HVMQYGNKTI STMKVMQFQG MKR.

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.

Specifications

• Antigen: LGMN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LGMN
• Gene Alias: AEP; AI746452; Asparaginyl endopeptidase; AU022324; cb173; cb460; cysteine protease 1; legumain; Lgmn; LGMN1; preprolegumain; protease, cysteine 1; protease, cysteine, 1; protease, cysteine, 1 (legumain); PRSC1; PRSC1EC 3.4.22.34; sb:cb173; wu:fa98g05; wu:fj92g08; zgc:76953
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19141, 5641, 63865
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 2.01 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: O89017, Q99538, Q9R0J8
• Gene Symbols: LGMN
• Immunogen: Recombinant protein (or fragment).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG