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Invitrogen™ LGI4 Polyclonal Antibody

Product Code. 12848692
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Quantity:
100 μg
Unit Size:
100µg
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12848692 100 μg 100µg
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Product Code. 12848692 Supplier Invitrogen™ Supplier No. PA520514

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-20514 can be used with blocking peptide PEP-0634.

The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LGI4
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene LGI4
Gene Accession No. Q8K1S1, Q8N135
Gene Alias clp; leucine rich repeat LGI family member 4; leucine-rich glioma inactivated protein 4; leucine-rich glioma-inactivated gene 4; leucine-rich glioma-inactivated protein 4; Leucine-rich repeat LGI family member 4; leucine-rich repeat LGI family, member 4; LGI1-like protein 3; LGI4; Lgil3; UNQ6515/PRO21485
Gene Symbols LGI4
Host Species Rabbit
Immunogen A 17 amino acid peptide from near the carboxy terminus of human LGI4.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 163175, 243914, 361549
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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