LGI3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA520494

Product Code. 12828672

Description

A suggested positive control is human brain tissue lysate. PA5-20494 can be used with blocking peptide PEP-0614.

The leucine-rich, glioma inactivated gene 3 (LGI3) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI3 have not been found to be associated with ADTLE. LGI3 expression is induced in rat astrocyte cultures by the amyloid beta (Abeta) peptide and accumulated on neuronal plasma membranes of aged monkey brains and co-localized with Abeta.

Specifications

• Antigen: LGI3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Lgi3
• Gene Alias: AI841179; AW049851; Leubrin; leucine rich repeat LGI family member 3; leucine-rich glioma-inactivated protein 3; Leucine-rich repeat LGI family member 3; leucine-rich repeat LGI family, member 3; LGI1-like protein 4; LGI3; LGIL4; UNQ8190/PRO23199
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 203190, 213469, 306013
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8K406, Q8N145
• Gene Symbols: Lgi3
• Immunogen: a 12 amino acid peptide from near the center of human LGI3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG