Lestaurtinib, Tocris Bioscience™

Description

JAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB

Potent JAK2, FLT3 and TrkA inhibitor (IC50 values are 0.9, 3 and < 25 nM, respectively). Also inhibits Aurora kinase A and B (IC50 values are 8.1 and 2.3 nM, respectively) and prevents STAT5 phosphorylation (IC50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo.

Specifications

• CAS: 111358-88-4
• Molecular Formula: C26H21N3O4
• MDL Number: MFCD09840836,MFCD12828858
• Quantity: 1 mg
• Synonym: lestaurtinib, unii-do989gc5d1, lestaurtinib usan/inn, 9,12-epoxy-1h-diindolo 1,2,3-fg:3',2',1'-kl pyrrolo 3,4-i 1,6 benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-hydroxymethyl-9-methyl-, 9s,10s,12r, lestaurtinib usan:inn, 4otg, d0v9wf, dsstox_cid_26778, dsstox_rid_81897
• InChI Key: UIARLYUEJFELEN-LROUJFHJSA-N
• SMILES: C[C@]12O[C@H](C[C@]1(O)CO)N1C3=C(C=CC=C3)C3=C1C1=C(C4=C3C(=O)NC4)C3=CC=CC=C3N21
• IUPAC Name: (15S,16S,18R)-16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),7(27),8,10,12,20(25),21,23-nonaen-3-one
• Molecular Weight (g/mol): 439.47
• PubChem CID: 126565
• Formula Weight: 439.46
• Percent Purity: >99%
• Chemical Name or Material: Lestaurtinib