Lestaurtinib, MedChemExpress

MedChemExpress Lestaurtinib (CEP-701) is an orally active and selective RPTKs (receptor protein tyrosine kinase) inhibitor, competitively inhibits ATP binding to the TrkA/B/C domain. Lestaurtinib inhibits RPTKs phosphorylation, with IC50s of 2, 25 and 0.9 nM for FLT3, TrkA and JAK2, respectively. Lestaurtinib induces apoptosis and cycle arrest, also can inhibit growth of tumor.

Brand:  Medchem Express HY-50867

Product Code. 16490578

Description

Lestaurtinib (CEP-701) is an orally active and selective RPTKs (receptor protein tyrosine kinase) inhibitor, competitively inhibits ATP binding to the TrkA/B/C domain. Lestaurtinib inhibits RPTKs phosphorylation, with IC50s of 2, 25 and 0.9 nM for FLT3, TrkA and JAK2, respectively. Lestaurtinib induces apoptosis and cycle arrest, also can inhibit growth of tumor.

Specifications

• Chemical Name or Material: Lestaurtinib
• Color: White
• Molecular Formula: C₂₆H₂₁N₃O₄
• Synonym: CEP-701 KT-5555
• SMILES: O=C(NC1)C2=C1C3=C(C4=C52)N(C6=C3C=CC=C6)[C@@]([C@@](O)(CO)C7)(C)O[C@H]7N4C8=C5C=CC=C8
• Formula Weight: 439.46
• Physical Form: Solid

• CAS: 111358-88-4
• Purity Grade Notes: Research
• Quantity: 5 mg
• Solubility Information: DMSO : 50 mg/mL (113.78 mM; Need ultrasonic)
• Molecular Weight (g/mol): 439.46
• Grade: Research
• For Use With (Application): Cancer-Kinase/protease

Research purposes only