Invitrogen™ LDHA Recombinant Rabbit Monoclonal Antibody (23GB6060), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA552976

Product Code. 30088346

Description

Lactate dehydrogenase (LDH) is the enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+. In mammals, the enzyme is encoded by three genes: LDHA (M or muscle form), LDHB (H or heart form), and LDHC (X or testis form). The three human LDHs have 84-89% sequence similarities and 69-75% amino acid identities. There are five different LDH isoenzymes based on the proportion of M and H chains existing in the LDH tetrameric structure. The LDHA is hypoxia inducible and its expression is directly controlled by the transcriptional activity of the hypoxia inducible factor 1a (HIF1a). LDHB is also known to be upregulated in many cancers. Mutations in the LDHA gene can lead to Glycogen storage disease 11 (GSD11).

Specifications

• Antigen: LDHA
• Classification: Recombinant Monoclonal
• Concentration: 0.6 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P00338, P04642, P06151, P19629
• Gene Symbols: LDHA
• Immunogen: A synthesized peptide derived from human Lactate Dehydrogenase (254-300AA).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Clone: 23GB6060
• Conjugate: Unconjugated
• Gene: LDHA
• Gene Alias: Cell proliferation-inducing gene 19 protein; epididymis secretory sperm binding protein Li 133P; GSD11; HEL-S-133P; l7R2; Lactate Dehydrogenase; lactate dehydrogenase 1, A chain; lactate dehydrogenase 3, C chain, sperm specific; lactate dehydrogenase A; lactate dehydrogenase A4; lactate dehydrogenase A-like; lactate dehydrogenase C; lactate dehydrogenase C variant 3; lactate dehydrogenase M; lactate dehydrogenase-A; lactate dehydrogenase-M; lactate dehydrogenase-M (EC 1.1.1.27); Lactic Dehydrogenase; LDH; LDH muscle subunit; LDH testis subunit; Ldh1; Ldh-1; Ldh3; Ldha; LDH-A; ldha protein; ldha1; LDH-A4 muscle-specific isozyme; glycolytic enzyme; Ldhc; LDH-C; Ldhm; LDH-M; LDH-X; L-lactate dehydrogenase; L-lactate dehydrogenase A chain; L-lactate dehydrogenase C chain; M-LDH; OTTHUMP00000165206; PIG19; proliferation-inducing gene 19; renal carcinoma antigen NY-REN-59
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16828, 24533, 29634, 3939
• Content And Storage: -20°C
• Form: Liquid