Invitrogen™ LDB3 Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA518418

Product Code. 11336393

Description

This antibody is predicted to react with canine, mouse, porcine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 1,000.

This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.

Specifications

• Antigen: LDB3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LDB3
• Gene Alias: AW742271; cardiomyopathy, dilated 1C (autosomal dominant); CMD1C; CMH24; CMPD3; cypher; FLJ35865; HGNC:15710; KIAA01613; KIAA0613; LDB3; LDB3Z1; LDB3Z4; LIM domain binding 3; LIM domain-binding protein 3; LVNC3; MFM4; ORACLE; oracle protein; PDLIM6; PDZ and LIM domain 6; PDZ-LIM domain protein; protein cypher; Protein oracle; RGD1564875; ZASP; Z-band alternatively spliced PDZ motif protein; Z-band alternatively spliced PDZ-motif protein
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 11155
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O75112
• Gene Symbols: LDB3
• Immunogen: Synthetic peptide sequence (KSQNKPEDEADE) corresponding to the internal amino acids of LDB3 (aa 251-263).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG