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LCK Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Product Code. 16802975 Shop All Proteintech Products
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20 μL
150 μL
Unit Size:
150µL
20µL
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16802975 20 μL 20µL
16892965 150 μL 150µL
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Product Code. 16802975 Supplier Proteintech Supplier No. 244971AP20UL

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Description

Rabbit Polyclonal Antibody

LCK is a member of the Src-family tyrosine kinase, which are essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, LCK phosphorylates the ITAM motives in its zeta subunits establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by LCK and activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. The majority of LCK is localized to the plasma membrane, however, there is also a significant fraction associated with the Golgi apparatus which may contribute to Raf activation under conditions of weak stimulation through the TCR. LCK contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors. Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternatively splice variants of the LCK gene encoding different isoforms of the protein have been found.

Specifications

Antigen LCK
Applications Western Blot
Classification Polyclonal
Concentration 0.51 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene LCK
Gene Accession No. P06239, P06240
Gene Alias LCK, LSK, p56 LCK, p56lck, pp58lck, Protein YT16, Proto oncogene Lck, Tyrosine protein kinase Lck, YT16
Gene Symbols LCK
Host Species Rabbit
Immunogen LCK Fusion Protein Ag21475
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16818, 3932
Target Species Mouse, Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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