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LC3B Polyclonal Antibody, Invitrogen™

Product Code. 11594853
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Quantity:
150 μL
Unit Size:
150µL
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Product Code. Quantity unitSize
11594853 150 μL 150µL
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Product Code. 11594853 Supplier Invitrogen Supplier No. OSM00027W

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Description

Sheep Polyclonal Antibody

Reconstitute with 150 μL of distilled water.

LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3 B) in humans, is encoded by the gene MAP1LC3B (Microtubule-associated proteins 1A/1B light chain 3B). LC3B is associated with microtubule assembly and important is in neurogenesis. Recent studies indicate that LC3B plays a vital role in autophagy, a process that involves the bulk degradation of cytoplasmic component. Three human LC3 isoforms undergo post-translational modifications during autophagy. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). LC3B is a microtubule-associated protein that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3B may play a role in processes involving cancer, aging, metabolic and neurodegenerative disorders and cardiovascular/pulmonary diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LC3B
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation whole serum with no preservative
Gene MAP1LC3B
Gene Accession No. Q9GZQ8
Gene Alias MAP1A/MAP1B LC3 B, Map1lc3b
Gene Symbols MAP1LC3B
Host Species Sheep
Immunogen A synthetic peptide from human microtubule-associated proteins 1A/1B light chain 3B
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 81631
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Lyophilized
Isotype IgG
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