LC3B Polyclonal Antibody, Invitrogen™

Sheep Polyclonal Antibody

Brand:  Invitrogen OSM00027W

Product Code. 11594853

Description

Reconstitute with 150 μL of distilled water.

LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3 B) in humans, is encoded by the gene MAP1LC3B (Microtubule-associated proteins 1A/1B light chain 3B). LC3B is associated with microtubule assembly and important is in neurogenesis. Recent studies indicate that LC3B plays a vital role in autophagy, a process that involves the bulk degradation of cytoplasmic component. Three human LC3 isoforms undergo post-translational modifications during autophagy. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). LC3B is a microtubule-associated protein that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3B may play a role in processes involving cancer, aging, metabolic and neurodegenerative disorders and cardiovascular/pulmonary diseases.

Specifications

• Antigen: LC3B
• Classification: Polyclonal
• Formulation: whole serum with no preservative
• Gene Accession No.: Q9GZQ8
• Gene Symbols: MAP1LC3B
• Immunogen: A synthetic peptide from human microtubule-associated proteins 1A/1B light chain 3B
• Regulatory Status: RUO
• Gene ID (Entrez): 81631
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized

• Applications: Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Gene: MAP1LC3B
• Gene Alias: MAP1A/MAP1B LC3 B, Map1lc3b
• Host Species: Sheep
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG