Invitrogen™ Latexin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA523253

Product Code. 13297158

Description

Latexin Polyclonal Antibody for Western Blot, IHC (P), Flow

Latexin, also known as LXN, is a carboxypeptidase A inhibitor found in mammals, and it shares structural similarities with cystatin C, suggesting its role in protein abundance regulation. The LXN gene is located on chromosome 3, specifically at 3q25.32, encompassing 5 exons and coding for a protein of 222 amino acids. Latexin is identified as a molecular marker in the developing rat brain and is known for its tumor suppressive activities. With a molecular weight of 29 kDa, LXN is highly expressed in macrophages and plays a significant role in the inflammatory immune response, including regulating macrophage polarity and enhancing tumor immune surveillance. Research involving a Lxn knockout mouse model has demonstrated its importance in the regulation of hematopoietic stem cell function, suggesting its involvement in cellular homeostasis and survival mechanisms. Additionally, latexin contributes to sex dimorphism in hematopoiesis through gender-specific differential expression of microRNA, indicating its nuanced role in genetic regulation and cellular processes.

Specifications

• Antigen: Latexin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LXN
• Gene Alias: ECI; endogenous carboxypeptidase inhibitor; Latexin; latexin protein; Lxn; MUM; Protein MUM; TCI; tissue carboxypeptidase inhibitor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17035, 56925, 59073, 781644
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide
• Gene Accession No.: P70202, Q64361, Q9BS40
• Gene Symbols: LXN
• Immunogen: A portion of amino acids 200-222 of human Latexin.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Bovine
• Product Type: Antibody
• Isotype: IgG