LAT Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA579583

Product Code. 15915155

Description

The synthetic peptide sequence is 242-262aa, QEAEEVEEEGAPDYENLQELN Add 0.2 mL of distilled water, will yield a concentration of 500 μg/mL.

LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.

Specifications

• Antigen: LAT
• Classification: Polyclonal
• Formulation: PBS with 5MG BSA, 5MG BSA and 0.05MG sodium azide, 0.05MG sodium azide, 0.05MG thimerosal, 0.05MG thimerosal
• Gene Accession No.: O43561
• Gene Symbols: LAT
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human LAT.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Gene: LAT
• Gene Alias: Linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, pp36, p36-38, LAT
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27040
• Content And Storage: -20°C
• Form: Lyophilized