Invitrogen™ Lassa virus RING finger protein Z Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5112046

Product Code. 17109913

Description

Lassa virus RING finger protein Z Polyclonal Antibody for Western Blot

Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. Also selectively represses protein production by associating with host eIF4E.

Specifications

• Antigen: Lassa virus RING finger protein Z
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Alias: Lassa virus
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of Lassa virus RING finger protein Z (Lassa virus (strain mouse/Sierra Leone/Josiah/1976)). The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.11 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG