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Invitrogen™ Lass5 Polyclonal Antibody
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Product Code. 12808752
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Quantity:
100 μg
Unit Size:
100µg
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12808752 100 μg 100µg
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Product Code. 12808752 Supplier Invitrogen™ Supplier No. PA520570

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-20570 can be used with blocking peptide PEP-0690.

The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.
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Specifica

Antigen Lass5
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CERS5
Gene Accession No. Q8N5B7, Q9D6K9
Gene Alias 2310081H14Rik; AU045339; AW544927; Ceramide synthase 5; CerS5; LAG1 homolog, ceramide synthase 5; LAG1 longevity assurance homolog 5; LASS5; longevity assurance homolog 5; Sphingosine N-acyltransferase CERS5; TRAM homolog 4; translocating chain-associating membrane protein homolog 4; Trh4
Gene Symbols CERS5
Host Species Rabbit
Immunogen An 18 amino acid peptide near the amino terminus of the human LASS5.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 366984, 71949, 91012
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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