missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. STEMCELL Technologies Lapatinib​

STEMCELL Technologies Lapatinib​

Product Code. 17130192
Encompass_Preferred
Click to view available options
Quantity:
10 mg
100 mg
Unit Size:
100mg
10mg
This item is not returnable. View return policy

Product Code. 17130192

Brand: STEMCELL Technologies 73242

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Tyrosine kinase inhibitor; Inhibits EGFR and HER2

  • Lapatinib is a selective dual inhibitor of epidermal growth factor receptor (EGFR, ERBB1) and human epidermal growth factor receptor 2 (HER2, ERBB2), each with an IC50 of about 10 nM (Rusnak et al.) It binds reversibly, but with a very slow off-rate, to the ATP binding pocket in an inactive-like conformation, thus preventing autophosphorylation
  • Binding is very potent, with Ki values of 3 and 13 nM to EGFR and HER2 respectively (Wood et al.)
  • Induces apoptosis in cells overexpressing EGFR and/or HER2, and inhibits tumor growth in a mouse xenograft model (Xia et al.)

Specifications

CAS 231277-92-2
Synonym GSK 572016; GW 572016; Tyverb; GW2016
Quantity 10 mg
Molecular Formula C29H26ClFN4O4S
Purity ≥98%
Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.