LAP Mouse anti-Human, PE, Clone: FNLAP, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9829-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15557236

Quantity Price
1 £ 188.93 / 100 tests
Estimated Shipment date
from Supplier 03-05-2017
Add to basket


Description and Specification

Specification

Gene Alias Pro-TGF beta 1, LAP/TGF beta 1
Host Species Mouse
Concentration 5μL (0.5μg)/test
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human
Isotype IgG1
Antigen LAP
Format Conjugated
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Conjugate PE
Applications Flow Cytometry
Regulatory Status RUO
Quantity 100 tests
Clone FNLAP
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.

The FNLAP monoclonal antibody reacts with human latency associated peptide (LAP, pro-TGF beta 1, LAP/TGF beta 1). Many different cells produce TGF beta and it mediates effects on the proliferation, differentiation and function of many cell types. TGF beta is synthesized as a precursor that contains LAP at the N-terminus and mature TGF beta at the C-terminus. Processing and cleavage of the precursor protein between amino acids 278 and 279 results in the formation of LAP dimers and TGF beta dimers that then non-covalently associate with each other to form the small latent TGF beta complex. LAP is secreted and can be found in the extracellular matrix. In addition, LAP can also be expressed on platelets and activated regulatory T cells. It is believed that this surface-expressed LAP is due to the binding of LAP to GARP (LRRC32), which is a transmembrane protein that is also found at high levels on platelets and activated regulatory T cells.