Lamin A/C Mouse, Clone: 4A7, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9688-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15567606

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Description and Specification

Specification

Format Purified
Applications Enzyme Linked Immunosorbent Assay
Applications Immunocytochemistry
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Applications Western Blotting
Gene Alias LMNA, LMNC
Isotype IgG1
Quantity 100μg
Concentration 0.5mg/mL
Species Reactivity Hamster, Human, Mouse, Rabbit
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Storage Requirements Store at 2-8°C.
Host Species Mouse
Conjugate Unlabeled
Antigen Lamin A/C
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone 4A7
Regulatory Status RUO

The monoclonal antibody 4A7 recognizes human, mouse, rabbit and hamster lamin A/C. Lamins are nuclear intermediate filament proteins that provide framework for the nuclear envelope, maintain cell morphology, and protect the nucleus from mechanical, thermal, and oxidative stresses. Lamins also play a role in nuclear assembly, chromatin organization, DNA replication, RNA transcription, cell signaling, and apoptosis. Lamin C is a splice variant of Lamin A and both are A-type lamins. Lamin A and C are crucial for skeletal and cardiac development and function. Defects in A-type lamins result in cardiomyopathy, muscular dystrophy, peripheral neuropathy, lipodystrophy, restrictive dermopathy, and progeroid disorders.