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  7. Laduviglusib trihydrochloride, MedChemExpress

Laduviglusib trihydrochloride, MedChemExpress

Product Code. 16453598
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Product Code. 16453598

Brand: Medchem Express HY10182B10mg

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Description

MedChemExpress Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM.

Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy.

Specifications

Chemical Name or Material Laduviglusib trihydrochloride
CAS 1782235-14-6
Color White
Purity Grade Notes Research
Molecular Formula C22H21Cl5N8
Quantity 10 mg
Synonym CHIR-99021 trihydrochloride CT99021 trihydrochloride
Solubility Information DMSO : ≥ 32 mg/mL (55.68 mM) ∣H2O : 19 mg/mL (33.06 mM; Need ultrasonic and warming)
SMILES N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl.[H]Cl.[H]Cl
Molecular Weight (g/mol) 574.72
Formula Weight 574.72
Percent Purity 98.01%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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