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Laduviglusib, MedChemExpress

Product Code. 16456317
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Product Code. 16456317

Brand: Medchem Express HY10182

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Description

MedChemExpress Laduviglusib (CHIR-99021) is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy.

Laduviglusib (CHIR-99021) is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy.

Specifications

Chemical Name or Material Laduviglusib
CAS 252917-06-9
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C22H18Cl2N8
Quantity 5 mg
Synonym CHIR-99021 CT99021
Solubility Information DMSO : 16.67 mg/mL (35.82 mM; Need ultrasonic)
SMILES N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C
Molecular Weight (g/mol) 465.34
Formula Weight 465.34
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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