Laduviglusib, MedChemExpress

Product Code.	Quantity	unitSize
16456317	5 mg	5mg
16419996	50 mg	50mg
16041282	10 mg	10mg
16414696	100 mg	100mg

Product Code. 16456317

Brand: Medchem Express HY10182

Description

MedChemExpress Laduviglusib (CHIR-99021) is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy.

Laduviglusib (CHIR-99021) is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy.

Specifications

• Chemical Name or Material: Laduviglusib
• CAS: 252917-06-9
• Color: Light Yellow
• Purity Grade Notes: Research
• Molecular Formula: C₂₂H₁₈Cl₂N₈
• Quantity: 5 mg
• Synonym: CHIR-99021 CT99021
• Solubility Information: DMSO : 16.67 mg/mL (35.82 mM; Need ultrasonic)
• SMILES: N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C
• Molecular Weight (g/mol): 465.34
• Formula Weight: 465.34
• Percent Purity: 98.0%
• Grade: Research
• Physical Form: Solid
• For Use With (Application): Cancer-Kinase/protease

Research purposes only