p21 WAF1 Ab-11 Mouse Monoclonal Antibody, Epredia™

Ensure accurate, reproducible results with the Epredia™ p21^WAF1 Ab-11, Mouse Monoclonal Antibody.

Brand:  Epredia MS-891-P1

Product Code. 12672547

Description

p21^WAF1/Cip1/Sdi1/Pic1 is a tumor suppressor protein. Expression of p21^WAF1 is induced by wild type, but not mutant, p53 suppressor protein. The p21^WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression. It also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process.

Host Species: Mouse

Clone: CP74

Isotype: IgG2b

Species Reactivity: Human and Rat. Others not known.

Epitope: aa 1-80

Immunogen: Full-length human recombinant p21 protein

Molecular Weight: 21kDa

Positive Control: Raji, PC12 cells

Cellular Localization: Nuclear

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting
• Immunoprecipitation (Native verified)
• Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: p21superscriptWAF1superscript Ab-11
• Classification: Monoclonal
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 500 μL
• Research Discipline: Cell Cycle
• Target Species: Human, Rat
• Isotype: IgG2b

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: CP74
• Conjugate: Unconjugated
• Immunogen: Full length human recombinant p21 protein
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated